SilverJakler

In E17, can't you pick any sprite with any gender?

Yeah sprites aren't locked into a specific gender anymore in E17 (which is great because I wanted to play as a male Decibel).

Generally speaking NPCs refer to the protag as they/them, although in a couple situations they react differently depending on your gender (as explained by seki).

I don't think playing as male or female grants you anything at all in the long term. Playing NB gives you 1 more rep point with Adrienn and that's about it.

Oh wow, that's awesome! Thanks guys, I've been out of the game for a while so I didn't know.