On my mono fire run (just beat Shade) Numel/Camerupt has been essential in every single major battle so far, either KO'ing the opponent's ace or at least 3 pokes. If Numel wasn't available early on I probably would've had a way harder time.
Also speed boost Blaziken in my first run because he's in ubers for a reason. Gets better and better in the late game, solo'ing Samson and taking down 4 of Charlotte's pokes as an example.