Howdy, this has been a problem for several versions of the game and thus, for a few years now. I just didn't realize it was caused by Rejuvenation itself until recently.
Basically, while I'm playing the game and seemingly at random, my entire laptop screen will go black. Then, a white box with an X that looks like it's for a webpage will appear in the corner. My desktop will soon reappear, though my wallpaper will still be black, and Rejuvenation will crash (with no error window or anything, the game simply closes itself). This is a pretty severe issue since it's affecting my laptop display as a whole, and I really hope I can either figure out what exactly is causing the issue, or bring awareness to the devs that this is a thing that's happening. I lost pretty substantial progress today on my fresh nuzlocke as a result of such a crash, since I redownloaded the game last night and forgot about my previous experiences with the crash.
As some extra, possibly relevant information, I run Windows 11, and my device specs are attached.