Another thing to note during the ending events of Blacksteep Castle, Madame X stabbed Melia invoking the power of the Archetype within her. But then during the events where you first meet Angie, Angie does a ritual which would kill Melia, and sends her soul away too. But it did not, and with the Archetype acting as a backup generator. What if the ritual damaged the stability of the Archetype within Melia. Which could slowly be killing Melia which could be scene as the Genus Syndrome.